HY has reported positive results from its research on the patented probiotic 'HY7715' related to brain aging. In animal experiments, there was a decrease in aging-related substances in the blood, and indicators of blood-brain barrier function and neuroinflammation showed improvement.
On November 10, HY announced that the research findings on the probiotic 'HY7715 (Lactiplantibacillus plantarum HY7715)' were published in the international journal 'Journal of Microbiology and Biotechnology.'
HY7715 is a lactic acid bacterium developed by HY, isolated from kimchi. In this study, live and heat-treated forms of HY7715 were administered to an artificially aged animal model for eight weeks, after which changes in blood, brain and intestinal tissues, and gut microbiota were analyzed.
The results showed that the group receiving HY7715 had reduced levels of advanced glycation end products (AGEs), a blood substance associated with aging. Compared to the aging control group, the live bacteria group showed a reduction of about 61%, while the heat-treated group showed a reduction of about 65%.
Indicators of blood-brain barrier (BBB) permeability also decreased by approximately 79% in the live bacteria group and 82% in the heat-treated group. There was a reduction in gene expression related to inflammation and cellular aging in brain tissue, along with improvements in antioxidant defense indicators.
Changes were also observed in the gut environment. Indicators related to barrier maintenance and inflammation in colon tissue improved, and the proportion of beneficial gut bacteria, Bifidobacterium, increased in both treatment groups.
However, this study is still in the animal testing phase, and further clinical research is needed to determine if the same effects occur in humans.
HY plans to expand its probiotic research into areas such as muscle, brain, and gut health, continuing its work on microbiome-based healthy aging.
Kim Joo-yeon, head of HY's New Material Development Team, stated, "This research is significant as it confirms the effects of both live and heat-treated HY7715 on changes in the brain and gut due to aging. We will continue to accumulate scientific evidence based on our unique strains and pursue research on healthy aging utilizing the microbiome."
* This article has been translated by AI.
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